MAPK15 Protects from Oxidative Stress-Dependent Cellular Senescence by Inducing the Mitophagic Process

We investigated the effects of thyroid state on mechanisms underlying rat heart mitochondrial capacity to remove H2O2 produced by an exogenous source. The removal rates were higher in presence respiratory substrates independently from and hyperthyroid than hypothyroid preparations. state-linked changes rates, mirrored those release showing that endogenous do not compete for removing system. Mitochondrial content coenzyme Q9 Q10 was lower hypothyroidism hyperthyroidism suggesting production are due ubiquinone content. antioxidant enzyme inhibitors indicated contribution each is dependent state. This supported enzymatic activity measurements. Pharmacological inhibition also showed overall percentage processes, as well non-enzymatic affected Cytochrome levels, inferred light emission measurements, western blot determination cytochrome c, preparations supporting idea levels reducing compounds modified opposite way Further support obtained whole capacity, which provides evaluation systems, different cytochromes, assigned scavenging,